Isotopically Labeled Compounds
Medchemexpress LLC Amlodipine-d4 | 1185246-14-3 | 98.5% | 5 MG
Amlodipine-d4 is a deuterium labeled Amlodipine. Amlodipine is an antianginal agent and an orally active dihydropyridine calcium channel blocker. It functions by blocking voltage-dependent L-type calcium channels, which inhibits the initial influx of calcium. Amlodipine can be utilized for the research of high blood pressure and cancer.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cholesterol-d6-1 | 92543-08-3 | 99.82% | 392.69 | 1 MG
Cholesterol-d6-1 is deuterium labeled Cholesterol, a primary sterol in mammals that makes up 20-25% of the plasma membrane's structural component. It plays a significant role in determining the fluidity and permeability characteristics of the membrane, as well as the function of transporters and signaling proteins. It also acts as an endogenous estrogen-related receptor α (ERRα) agonist.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Pitavastatin-d4 sodium | 574705-92-3 | 99.7% | 1 MG
Pitavastatin-d4 sodium is a deuterium-labeled version of Pitavastatin sodium. Deuteration, the process of incorporating stable heavy isotopes of hydrogen (deuterium) into drug molecules, has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Nortriptyline (hydrochloride) 894-71-3 10mM (in 1mL DMSO)
Nortriptyline hydrochloride (CAS 894-71-3) is a dibenzocycloheptene-derived tricyclic antidepressant that inhibits monoamine reuptake transporters It selectively blocks the norepinephrine transporter (NET) with a Ki of 3 4 nM and inhibits the serotonin transporter (SERT) with a Ki of 161 nM thereby increasing synaptic concentrations of these neurotransmitters in the central nervous system In vitro nortriptyline dose-dependently suppresses spontaneous migration and chemotaxis of human polymorphonuclear cells In vivo studies in rodents indicate partial blockade of noradrenaline depletion in nerve terminals at higher doses Nortriptyline is frequently employed in research on monoaminergic neurotransmission and antidepressant pharmacology
Medchemexpress LLC Memantine-d6 (hydrochloride) | 1189713-18-5 | 99.8% | 500 UG
Memantine-d6 (hydrochloride) is a deuterium labeled Memantine hydrochloride. It functions as a moderate affinity, uncompetitive NMDA receptor antagonist, inhibiting CYP2B6 and CYP2D6. This compound is intended for research use only, primarily as a tracer and internal standard for quantitative analysis. Deuteration, involving the incorporation of stable heavy isotopes into drug molecules, is utilized for quantitation during drug development and may influence pharmacokinetic and metabolic profiles.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes incorporated into drug molecules.
- Deuteration has the potential to affect pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories Dimethyl Sulfoxide-D6 (D, 99.9%) +0.03% V/V Tms, 10 G, 2206-27-1
Dimethyl Sulfoxide-D6 (D, 99.9%) +0.03% V/V Tms, 10 G, 2206-27-1
Cambridge Isotope Laboratories ISOPROPANOL-D8 (D, 99%), 25 G, 22739-76-0
ISOPROPANOL-D8 (D, 99%), 25 G, 22739-76-0
Cambridge Isotope Laboratories Methylene Chloride-d2 (d, 99.9%), 1665-00-5, MFCD00000882, 10x1 g
Chemical Formula: CD2Cl2, MW: 86.94, 99.8%, Synonyms: Dichloromethane; Methylene dichloride.